Our research focuses on anesthesiologic pharmacology, more specifically on pharmacometric modelling and simulation of data from clinical drug trials. The primary fields of our research currently focus on exploring the possibility to reduce opioid use with adjuvants added to opioid therapy in postoperative setting, finding out dosing schemes for different patient populations with pharmacometric methods, and to establish covariate effects that can be used in the future to individualize drug therapy. Our previous research has focused on explaining the between-subject variability in drug-drug-interactions (e.g. Saari et al., 2006, 2010), and PK-PD using pharmacometric modelling (Saari et al., 2012, 2014, Jeleazcov et al., 2014, Ashraf et al., 2018). Our recent interest has moved on finding a panel of biomarkers and individual characteristics that could be used to guide dosing in different patient populations. I am currently collaborating with highly synergistic and focused set of leading research groups both in Finland (University of Helsinki and University of Tampere) and abroad (McGill University, University of Uppsala and University of Erlangen-Nüremberg).
For further information, please send me a tweet (@tsaari1) or mail at teisaa@utu.fi!
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