Our research focuses on anesthesiologic pharmacology, more specifically on clinical drug trials and pharmacometric modelling of the clinical data. The cornerstones of our research are acute pain medicine and procedural sedation.
Currently, the primary fields of our research explore the possibility to reduce opioid use with adjuvants added to opioid therapy in postoperative setting. We aim to find out model informed dosing schemes for different patient populations using pharmacometric methods, and to establish covariate effects that can be used in the future to individualize drug therapy.
The ultimate goal of our research is to introduce precision medicine in anesthesia and analgesia to reduce the opioid use in acute pain medicine, and to discover biomarkers that can predict chronic pain development.
Recent publications:
Laaksonen M, Rinne J, Rahi M, Posti JP, Laitio R, Kivelev J, Saarenpää I, Laukka D, Frosen J, Ronkanen A, Bendel S, Langsjö J, Ala-Peijari M, Saunavaara J, Parkkola R, Nyman M, Martikainen IK, Dickens AM, Rinne J, Valtonen M, Saari T, Koivisto T, Bendel P, Roine T, Saraste A, Vahlberg T, Tanttari J, Laitio T. Effect of xenon on brain injury, neurological outcome, and survival in patients after aneurysmal subarachnoid hemorrhage – Study protocol for a randomized clinical trial. TRLS-D-23-00228, submitted.